Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions Klik for mere for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological aim and you will pharmacology regarding curcumin
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin ‘s the major element of the brand new purple color out-of turmeric, a keen Indian spice that is obtained from this new rhizome of one’s tropical plant Curcuma longa, and this belongs to the Zingiberaceae family unit members. In this part, i discuss the pharmacological situations from curcumin and you may explore the fresh molecular basics for those issues. We next comment the fresh confirmed and potential logical spends out-of curcumin. Curcumin is known over the years once the a restorative representative, but their system away from step is detailed. The brand new pharmacological outcomes of curcumin seem to be caused by good synergism off channels out-of poor biochemical interactions which have several biological plans within the interrelated signaling pathways. These types of needs include minerals eg cyclooxygenase, lipoxygenase and necessary protein kinases, and you may transcription points such as NF-?B, STAT and you can Nrf2. Modulation ones molecules impacts downstream affectors which make brand new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and antimicrobial situations from curcumin. Such consequences was basically checked-out within the clinical products out-of curcumin to own discomfort and inflammatory ailment, cancer tumors, Alzheimer disease, aerobic sickness, and you can diabetes. The newest products purchased varying dosage of curcuminwith different frequencies and you will stage, towards the general completion one large dosage away from curcumin from the amount of g must get healing outcomes. Read more
Curcumin: Synthesis, Emerging Role for the Aches Administration and you may Health Effects
Publication Part Samples of plant-derived pharmaceuticals which have end up being the interest from continued and you can rapid browse and you can innovation attention has, to date, become slightly scarce. Immediately after several years, the past 2 decades have been described as a 100-bend rise in the number of scientific articles penned a-year one are out-of relevance towards accessibility curcumin during the biomedicine. Read more
Build, synthesis and you may physical affairs out-of curcumin prodrugs
Book ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has some possible pharmacological effects and may also has actually therapeutic software a number of situation states, just like the discussed in detail in the previous part. However, the possibility medical effectiveness away from curcumin is limited from the the physicochemical attributes out-of terrible h2o solubility and you may imbalance, and therefore end in lowest bioavailability. Prodrugs away from curcumin render an easy way to update of biopharmaceutical and you may pharmacokinetic qualities, that can succeed exploitation of your pharmacological effects of curcumin. In this chapter, we very first feedback brand new physicochemical and pharmacokinetics out of curcumin. We then explain the appearance of curcumin prodrugs having increased liquids solubility and you can enhanced chemical compounds balance which might be converted back once again to totally free curcumin abreast of bioactivation during the vivo. I high light latest success in this region, with a concentrate on the structure, synthesis and you will comparison of prodrugs based on promoieties together with amino acids, efas, nucleic acids, dicarboxylic acids, and you may polymeric product eg hyaluronic acidic and you may polyethylene glycol. So it part contains the cause for optimisation of physicochemical and you may biopharmaceutical characteristics therefore the physical factors off curcumin prodrugs, into mission having fun with of them curcumin derivatives when you look at the clinical software. Read more